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Calcitriol
Calcitriol (INN), also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active metabolite of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D),〔("Nomenclature of Vitamin D. Recommendations 1981. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN) )" reproduced at the Queen Mary, University of London website. Retrieved 21 March 2010.〕 It was first identified by Michael F. Holick in work published in 1971. Calcitriol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, and possibly increasing the release of calcium into the blood from bone.〔Voet, Donald; Voet, Judith G. (2004). ''Biochemistry. Volume one. Biomolecules, mechanisms of enzyme action, and metabolism'', 3rd edition, pp. 663–664. New York: John Wiley & Sons. ISBN 0-471-25090-2.〕
== Nomenclature ==
Calcitriol usually refers specifically to 1,25-dihydroxycholecalciferol, but may also sometimes include 24,25-dihydroxycholecalciferol (when specified), the deactivated form of vitamin D.
Because cholecalciferol already has one hydroxyl group, only two are further specified in the nomenclature.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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