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| 1-(2-Pyrimidinyl)piperazine ： ウィキペディア英語版 |
Pyrimidinylpiperazine
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1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an α2-adrenergic receptor antagonist, and as a 5-HT1A receptor partial agonist to a much lesser extent. It does not appear to have any significant affinity for the D2 or α1-adrenergic receptors.
A number of pyrimidinylpiperazine derivatives are drugs, including:
* Buspirone - anxiolytic
* Dasatinib - anticancer agent
* Eptapirone - anxiolytic
* Gepirone - anxiolytic
* Ipsapirone - anxiolytic
* Piribedil - antiparkinsonian agent
* Revospirone - anxiolytic
* Tandospirone - anxiolytic
* Tirilazad - neuroprotective agent
* Umespirone - anxiolytic
* Zalospirone - anxiolytic
The anxiolytics are also classified as azapirones due to the azaspirodecanedione moiety in their structures. 1-PP is a common metabolite of most or all of the listed agents. Alnespirone, binospirone, and enilospirone, despite being azapirones, are not piperazines and therefore do not metabolize to 1-PP, and while perospirone and tiospirone are piperazines, they are instead benzothiazole-substituted piperazines and do not metabolize to 1-PP either.
== See also ==
* Pyridinylpiperazine
* Phenylpiperazine
* Diphenylmethylpiperazine
* Benzylpiperazine
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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