翻訳と辞書 Words near each other ・ 1-Pentyne ・ 1-Phenylethylamine ・ 1-phosphatidylinositol 4-kinase ・ 1-phosphatidylinositol-3-phosphate 5-kinase ・ 1-phosphatidylinositol-4-phosphate 5-kinase ・ 1-phosphatidylinositol-5-phosphate 4-kinase ・ 1-phosphofructokinase ・ 1-planar graph ・ 1-Propanol ・ 1-Pyrroline dehydrogenase ・ 1-pyrroline-4-hydroxy-2-carboxylate deaminase ・ 1-Pyrroline-5-carboxylate dehydrogenase ・ 1-Pyrroline-5-carboxylic acid ・ 1-Testosterone ・ 1-Tetracosanol ・ 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine ・ 1-(4-(Trifluoromethyl)phenyl)piperazine ・ 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide ・ 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase ・ 1-(Furan-2-yl)undecan-1-ol ・ 1-1 ・ 1-2-1-1 zone press ・ 1-2-3 ・ 1-2-3 (APO Hiking Society album) ・ 1-2-3 (fuel station) ・ 1-2-3 (Gloria Estefan and Miami Sound Machine song) ・ 1-2-3 (Howling Hex album) ・ 1-2-3 (Len Barry song) ・ 1-2-3 (The Chimes song) ・ 1-2-3 block Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine ： ウィキペディア英語版 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) is a psychoactive recreational drug of the piperazine class. 3C-PEP is related to ''meta''-cholorophenylpiperazine (mCPP) and phenethylamine that can be thought of as mCPP having a phenylethyl group attached to the nitrogen atom at its 4-position. It was first described in 1994 in a patent〔(【引用サイトリンク】first1 = Richard A )〕 disclosing a series of piperazine compounds as sigma receptor ligands. Later, it was discovered by researchers at the University of Maryland to be a highly potent dopamine reuptake inhibitor. Rather serendipitously, since the investigators were looking for compounds that bind to the sigma receptor as sigma ligands have been proposed as potential treatment of psychostimulant abuse including cocaine and methamphetamine abuse. == Pharmacology == 3C-PEP is one of the most potent dopamine transporter (DAT) ligand reported to date. It is highly selective for the dopamine transporter (DAT dissociation constant Ki = 0.04 nM) with relatively low affinity for the closely related Norepinephrine transporter NET (Ki = 1107 nM ) and the Serotonin Transporter SERT (Ki = 802 nM). In addition, the compound has little or no affinity for D2-like receptor (Ki = 327 nM), Serotonin 5-HT2 receptor, (Ki = 53 nM) Opioid receptor (Ki>10000 nM) and the PCP/NMDA receptor (Ki>10000 nM). With a DAT dissociation constant Ki of 0.04 nM, 3C-PEP is one of the most potent dopamine transporter ligand described to date in the literature. In comparison, cocaine which is a prototypical DAT ligand and reuptake inhibitor has a dissociation constant Ki of 435 nm thus making 3C-PEP about 10,000 times more potent than cocaine as a dopamine transporter inhibitor ''in vitro''. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.