|
1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18) is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. It was invented by the chemists Edward Knaus, Brent Warran and Theodore Ondrus in 1981.〔(Edward E. Knaus, Brent K. Warren, Theodore A. Ondrus. Analgesic substituted piperidylidene-2-sulfon(cyan)amide derivatives. US Patent 4468403 )〕 This compound was found to be around 10,000x more potent than morphine in animal studies. It has never been studied in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal. Tolerance and dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to carfentanil and so would most likely cause pronounced tachyphylaxis following repeated dosing, as is seen with the potent fentanyl analogues. It was recently found to be in several drugs seized by police in Canada. The seized drugs were believed to be a fentanyl analog but after analysis were identified as 1-(4-nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide. This is of great concern to health officials and police due to the extreme potency of this substance. ==See also== * W-15 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide」の詳細全文を読む スポンサード リンク
|