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・ 141st Aviation Training Regiment
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14-methoxydihydromorphinone
・ 14-Methoxymetopon
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14-methoxydihydromorphinone : ウィキペディア英語版
14-methoxydihydromorphinone

14-methoxydihydromorphinone is a semi-synthetic opioid related to 14-Methoxymetopon (14-MM) an opioid with a Ki of 0.15 nM, & 14-O-methyloxymorphone (14-OMO) with a Ki of 0.10 nM. By contrast oxymorphone has a Ki of 0.97 nM and morphine one of 6.55 nM (all at mu receptors). Inferring that both 14-OMO and 14-MM have a higher mu/kappa selectivity than oxymorphone. 〔(In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel mu opioid analgesic with reduced propensity to alter motor function. Eur J Pharm Sci. 2010 Sep 11;41(1):125-35. doi: 10.1016/j.ejps.2010.05.018. Epub 2010 Jun 18. )〕〔(Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions. Top Curr Chem. 2011;299:63-91. )〕
==See also==

5-methyldihydromorphone

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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