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2'-O-methylation : ウィキペディア英語版 | 2'-O-methylation
2'-''O''-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl group of the ribose moiety of a nucleoside. 2'-''O''-methylated nucleosides are mostly found in ribosomal RNA and small nuclear RNA and occur in the functionally essential regions of the ribosome and splicesome. Also, 2'-''O''-methylation of adenosine in an RNA prevents adenosine deaminase from editing it to an inosine. Recently a novel method to map 2'-''O'' ribose methylations by high throughput sequencing has been published. The method is quantitative and maps all modifications in a single experiment. == See also ==
*Small nucleolar RNA
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