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| 2,6-Dimethoxy-1,4-benzoquinone ： ウィキペディア英語版 |
2,6-Dimethoxybenzoquinone
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2,6-Dimethoxybenzoquinone (2,6-DMBQ) is a benzoquinone, a chemical compound found in ''Rauvolfia vomitoria''〔A note on the occurrence of 2,6-dimethoxybenzoquinone in Rauwolfia vomitoria. S. Morris Kupchan and Mang E. Obasi, Journal of the American Pharmaceutical Association, Volume 49, Issue 4, pages 257–258, April 1960, 〕 and in ''Tibouchina pulchra''.〔Plant anticancer agents. XI. 2,6-dimethoxybenzoquinone as a cytotoxic constituent of Tibouchina pulchra. Jones E., Ekundayo O. and Kingston D.G.I., Journal of natural products, Jul-Aug 1981, 〕
==Toxicity==
2,6-DMBQ is mutagenic,〔Canonero R; Poggi C Mutagenic activity of 2,6-dimethoxy-1,4-benzoquinone, produced during the nitrosation of dimethophrine, in V 79 cells. Bollettino della Societa italiana di biologia sperimentale (1988), 64(1), 61-8〕〔Brambilla G; Robbiano L; Cajelli E; Martelli A; Turmolini F; Mazzei M Cytotoxic, DNA-damaging and mutagenic properties of 2,6-dimethoxy-1,4-benzoquinone, formed by dimethophrine-nitrite interaction. The Journal of pharmacology and experimental therapeutics (1988), 244(3), 1011-5〕 cytotoxic,〔 genotoxic,〔Mazzei M; Roma G; Balbi A; Sottofattori E; Robbiano L Formation of 2,6-dimethoxy-1,4-benzoquinone, a highly genotoxic compound, from the reaction of sodium nitrite with the sympathomimetic drug dimethophrine in acidic aqueous solution. Il Farmaco; edizione scientifica (1988), 43(6), 523-38〕 and hepatotoxic.〔Moore, Gregory A.; Rossi, Luisa; Nicotera, Pierluigi; Orrenius, Sten; O'Brien, Peter J. Quinone toxicity in hepatocytes: studies on mitochondrial calcium release induced by benzoquinone derivatives. Archives of Biochemistry and Biophysics (1987), 259(2), 283-95.〕〔Siraki, Arno G.; Chan, Tom S.; O'Brien, Peter J. Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells. Toxicological Sciences (2004), 81(1), 148-159〕〔Chan, Katie; Jensen, Neil; O'Brien, Peter J. Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds. Journal of Applied Toxicology (2008), 28(5), 608-620.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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