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2-Carbomethoxytropinone : ウィキペディア英語版 | 2-Carbomethoxytropinone
|Section2= |Section3= |Section8= }} 2-Carbomethoxytropinone (2-CMT) is a commonly used organic intermediate in the synthesis of cocaine and its analogues. As of at least 1999 no reaction pathway has been discovered that synthesizes cocaine-like compounds without utilizing the reduction of 2-carbomethoxytropinone. The structure of cocaine was discovered by Richard Willstätter in 1898 after he synthesized it from 2-carbomethoxytropinone. Although it was originally believed that 2-CMT in nature was ultimately derived from ornithine and acetic acid, subsequent research has indicated other pathways exist for the biosynthesis of 2-CMT. A β-keto ester, 2-carbomethoxytropinone exists in equilibrium with its keto–enol tautomer. ==Synthesis==
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