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2-Methylimidazole : ウィキペディア英語版 | 2-Methylimidazole
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents. It is a precursor to a range of drugs and is a ligand in coordination chemistry. ==Synthesis and reactions== It is prepared by condensation of glyoxal, ammonia, and acetaldehyde, a Radziszewski reaction. Nitration gives 5-nitro derivative.〔Ebel, K., Koehler, H., Gamer, A. O., & Jäckh, R. "Imidazole and Derivatives." In Ullmann’s Encyclopedia of Industrial Chemistry; 2002 Wiley-VCH, 〕 2-Methylimidazole is a sterically hindered imidazole that is used to similuate the coordination of histidine to heme complexes. It can be deprotonated to make imidazolate-based coordination polymers.
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