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2-fluoroamphetamine : ウィキペディア英語版
2-Fluoroamphetamine

2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug. 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.
==Pharmacology==
Anorexiant dose (amount inhibiting food intake by 50% for 2 hours, given 1 hour earlier) = 15 mg/kg (rat; p.o.).〔E. Costa and S. Garattini (1970) ''Amphetamines and Related Compounds'', p.28, New York: Raven Press.〕
Analgesic dose (50% inhibition of response to tail-clamp) = 20 mg/kg (mouse; i.p.).〔
Effect on blood pressure: 0.5 mg/kg (rat; i.v.) produces an increase in BP of 29 mm.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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