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22R-Hydroxycholesterol
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22R-Hydroxycholesterol : ウィキペディア英語版
22R-Hydroxycholesterol

22''R''-Hydroxycholesterol, or (3β)-cholest-5-ene-3,22-diol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22''R''-hydroxycholesterol, which is subsequently hydroxlated again by P450scc to form 20α,22''R''-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone ((3β)-3-hydroxypregn-5-en-20-one),〔〔 the precursor to the steroid hormones.
It is an agonist of the liver X receptor.
== See also ==

* 20α,22''R''-Dihydroxycholesterol
* 27-Hydroxycholesterol

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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