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| 3-(p-Fluorobenzoyloxy)tropane ： ウィキペディア英語版 |
3-(p-Fluorobenzoyloxy)tropane
3β-(''p''-Fluorobenzoyloxy)tropane, (8-Methyl-8-azabicyclo()oct-3-yl 4-fluorobenzoic acid ester, 4-fluorotropacocaine, 3-Pseudotropyl-4-fluorobenzoate, 3-pseudotropyl-4-fluorobenzoate, pFBT) is a tropane derivative drug which acts as a local anaesthetic, having around 30% the stimulant potency of cocaine but around the same potency as a local anaesthetic. It has been investigated as a potential radiolabelled agent for studying receptor binding,〔Ali M. Emran. New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, 1991. p84. ISBN 0-306-44035-0〕 but was not adopted for this application. The main application for fluorotropacocaine however has been as a designer drug analogue of cocaine, first detected by the EMCDDA in 2008,〔Kavanagh P, Angelov D, O'Brien J, Fox J, O'Donnell C, Christie R, Power JD, McDermott SD. The syntheses and characterization 3β-(4-fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3α isomer. ''Drug Testing and Analysis''. 2011 Nov 18. PMID 22102564〕 and subsequently sold as an ingredient of various "bath salt" powder products, usually mixed in combination with other stimulant drugs such as caffeine, dimethocaine, desoxypipradrol or substituted cathinone derivatives.〔(An overview of new psychoactive substances and the outlets supplying them )〕〔Reitzel LA, Dalsgaard PW, Müller IB, Cornett C. Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish Internet company. ''Drug Testing and Analysis''. 2011 Nov 18. PMID 22102551〕
==See also==
* 4'-Fluorococaine
* Tropacocaine
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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