翻訳と辞書 Words near each other ・ 3-Hydroxybutanal ・ 3-hydroxybutyrate dehydrogenase ・ 3-hydroxybutyryl-CoA dehydratase ・ 3-hydroxybutyryl-CoA dehydrogenase ・ 3-hydroxybutyryl-CoA epimerase ・ 3-hydroxycyclohexanone dehydrogenase ・ 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase ・ 3-Hydroxyflavone ・ 3-hydroxyindolin-2-one monooxygenase ・ 3-hydroxyisobutyrate dehydrogenase ・ 3-Hydroxyisobutyric acid ・ 3-Hydroxyisobutyryl-CoA ・ 3-hydroxyisobutyryl-CoA hydrolase ・ 3-Hydroxykynurenine ・ 3-hydroxymethylcephem carbamoyltransferase ・ 3-Hydroxymorphinan ・ 3-Hydroxyoctanoic acid ・ 3-hydroxyoctanoyl-(acyl-carrier-protein) dehydratase ・ 3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase ・ 3-Hydroxypentanoic acid ・ 3-Hydroxyphenazepam ・ 3-hydroxyphenylacetate 6-hydroxylase ・ 3-Hydroxypicolinic acid ・ 3-hydroxypimeloyl-CoA dehydrogenase ・ 3-hydroxypropionate dehydrogenase ・ 3-hydroxypropionate dehydrogenase (NADP+) ・ 3-Hydroxypropionate pathway ・ 3-Hydroxypropionic acid ・ 3-hydroxypropionyl-CoA dehydratase ・ 3-hydroxypropionyl-CoA synthase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 3-Hydroxymorphinan ： ウィキペディア英語版 3-Hydroxymorphinan 3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family. It is the racemic version of norlevorphanol. The dextrorotatory stereoisomer of the compound is an active metabolite of dextromethorphan, dextrorphan, and 3-methoxymorphinan, and similarly to them has potent neuroprotective and neurotrophic effects on LTS- and MPTP-treated dopaminergic neurons of the nigrostriatal pathway, but notably without producing any neuropsychotoxic side effects (e.g., dissociation or hallucinations) or having any anticonvulsant actions. It does not seem to bind to the NMDA receptor,〔 and instead, its neuroprotective properties appear result from inhibition of glutamate release via the suppression of presynaptic voltage-dependent Ca2+ entry and protein kinase C activity. In any case, as such, the compound has been investigated as a potential antiparkinsonian agent. A prodrug, GCC1290K, has been developed on account of 3-HM's poor bioavailability (18%), and a New Drug Application has been approved for it by the United States Food and Drug Administration.〔 It is currently undergoing clinical trials for the treatment of Parkinson's disease.〔 3-HM's levorotatory stereoisomer, norlevorphanol, in contrast to (+)-3-HM, is an opioid analgesic. It was never marketed as such however, probably due to a combination of the facts that norlevorphanol has low bioavailability and that its potency is diminished compared to its ''N''-methylated analogue levorphanol. == See also == * Norlevorphanol 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「3-Hydroxymorphinan」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.