|
3-''O''-Methyldopa (3-OMD) is one of the most important metabolite of L-DOPA, that is used in the treatment of the Parkinson's disease, particularly to increase the dopamine levels . Catechol-O-methyl transferase is the enzyme in charge of 3-OMD formation, which is produced from L-DOPA in many organs. Nevertheless, its half-life (15 hours approximately) is longer than the L-DOPA 's half-life, which is about one hour.〔Parkinson’s Disease and movement disorders. Joseph Jankovic y Eduardo Tolosa. Ed. Lippincott Williams & Wilkins. Fifth Edition.〕 This means that it is accumulated in the plasma and the brain of chronic L-DOPA therapy patients such as people suffering from Parkinson disease. We can find it in high concentrations basically in two places: plasma and cerebral spinal fluid of Parkinson's disease.〔Parkinson y Discinesias. Abordaje diagnóstico y terapéutico. López del Val y Linazasoro Cristóbal. Ed. Médica Panamericana.〕 ==Effects== Recent studies suggest that 3-OMD has some effects on the chronic treatment of L-DOPA. There are some evidences about it: * Higher levels of dyskinesia. * L-DOPA related motor dysfunction. * Inhibition of striatal uptake of tyrosine. * Competition with L-DOPA for the blood–brain barrier transporter system. * Inhibition of dopamine release. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「3-O-Methyldopa」の詳細全文を読む スポンサード リンク
|