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3-aminoisobutyrate : ウィキペディア英語版
3-Aminoisobutyric acid

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3-Aminoisobutyric acid (or β-aminoisobutyric acid, 'BAIBA') is a product formed by the catabolism of thymine.
It has recently been postulated to play a role in cell metabolism, how body burns fat and regulates insulin, triglycerides, and total cholesterol.〔http://medicalxpress.com/news/2014-01-molecule-benefits.html〕
During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from exercising muscles to blood (concentration 2 to 3 µM in human serum). When BAIBA reaches the white fat tissue, it activates the expression of thermogenic genes via PPARα receptors, resulting in a browning of white fat cells.〔http://www.cell.com/cell-metabolism/retrieve/pii/S155041311300497X〕 One of the consequences of the BAIBA activity is the increase of the background metabolism of the BAIBA target cells.
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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