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| 3α-dihydroprogesterone ： ウィキペディア英語版 |
3α-Dihydroprogesterone
3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxy-4-pregnen-20-one, is an endogenous neurosteroid. It is biosynthesized by 3α-hydroxysteroid dehydrogenase from progesterone.〔 3α-DHP has been found to act as a positive allosteric modulator of the GABAA receptor and is described as being as active as allopregnanolone in regards to this action.〔 In accordance, it has anxiolytic effects in animals. 3α-DHP has also been found to inhibit the secretion of follicle-stimulating hormone (FSH) from the rat pituitary gland, demonstrating possible antigonadotropic properties.〔 Unlike the case of most other inhibitory neurosteroids, 3α-DHP production is not blocked by 5α-reductase inhibitors like finasteride.〔
==See also==
* 3β-Dihydroprogesterone
* 5α-Dihydroprogesterone
* 5β-Dihydroprogesterone
* Pregnanolone
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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