|
5α-Androstane-3β,17β-diol, also called 3β-androstanediol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen. In contrast, it does not bind to the androgen receptor. As a result of activation of the ERβ, 3β-diol has antiproliferative effects against prostate cancer cells and proliferative effects on breast cancer cells. 3β-Diol has been reported to also bind to ERα with low nanomolar affinity. Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not affect the GABAA receptor. Through the ERβ, 3β-diol positively regulates oxytocin neurons and signaling in the paraventricular nucleus of hypothalamus (PVN), and has been found to have antidepressant, anxiolytic, cognitive-enhancing,〔 and stress-relieving effects via this action. Androgens, including testosterone and dihydrotestosterone (DHT), are known to downregulate the hypothalamic-pituitary-adrenal axis (HPA axis), and this has been found to be due in part or full to their conversion into 3β-diol rather than to activation of the androgen receptor (AR).〔〔 A determination of the circulating levels of 3β-diol in humans found concentrations of 239 ± 76 pg/ml and 82 ± 45 pg/ml of the compound in normal male and female serum, respectively. ==See also== * 3α-Androstanediol * Epiandrosterone 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「5α-Androstane-3β,17β-diol」の詳細全文を読む スポンサード リンク
|