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3β-HSD : ウィキペディア英語版
3beta-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) () is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the cytochrome P450 family.〔 In humans, there are two 3β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes.
3β-HSD is also known as delta Δ5-4-isomerase, which catalyzes the oxidative conversion of Δ5-3-β-hydroxysteroids to the Δ4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.〔
The 3β-HSD complex is responsible for the conversion of:
* Pregnenolone to progesterone
* 17α-Hydroxypregnenolone to 17α-hydroxyprogesterone
* DHEA to androstenedione
* Androstenediol to testosterone
* Androstadienol to androstadienone
==Reaction==
3β-HSD belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in C21-steroid hormone metabolism and androgen and estrogen metabolism.
3β-HSD catalysis|catalyzes the chemical reaction:
:a 3β-hydroxy-Δ5-steroid + NAD+ \rightleftharpoons a 3-oxo-Δ5-steroid + NADH + H+
Thus, the two substrates of this enzyme are 3β-hydroxy-Δ5-steroid and NAD+, whereas its three products are 3-oxo-Δ5-steroid, NADH, and H+.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「3beta-Hydroxysteroid dehydrogenase」の詳細全文を読む



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