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|Section2= |Section7= |Section6= }} 4-Aminopyridine (4-AP, INN fampridine, USAN dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials ,〔http://www.acorda.com/pipeline_fampridine_sci1.asp〕 and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010.〔(FDA Approves Ampyra to Improve Walking in Adults with Multiple Sclerosis )〕 Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics〔〔http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=2586〕 and as Fampyra in Europe. In Canada, the medication has been approved for use by Health Canada since February 10, 2012.〔(Notice of Decision for FAMPYRA )〕 ==Production== 4-Aminopyridine is prepared by the decarbonylation of pyridine-4-carboxamide using sodium hypochlorite via the Hofmann rearrangement. The pyridine carboxamide is generated from the corresponding nitrile, which in turn is obtained from ammoxidation of 4-methylpyridine.〔Shinkichi Shimizu, Nanao Watanabe, Toshiaki Kataoka, Takayuki Shoji, Nobuyuki Abe, Sinji Morishita, Hisao Ichimura "Pyridine and Pyridine Derivatives" in "Ullmann's Encyclopedia of Industrial Chemistry" 2007; John Wiley & Sons: New York.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「4-Aminopyridine」の詳細全文を読む スポンサード リンク
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