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| 4-Bromofluorobenzene ： ウィキペディア英語版 |
|Section2=|Section3=|Section7=|Section8=}}4-Bromofluorobenzene is a halogenated aromatic organic compound with the formula C6H4BrF. It is a derivative of benzene, with a bromine atom bonded ''para'' to a fluorine atom. It has uses as a precursor to some pharmaceuticals, as an agrochemical intermediate, and in organic synthesis.(【引用サイトリンク】No. 460-00-4 ) Review of Toxicological Literature">url=http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/4-bfb_508.pdf )==Uses==The electronegativity (withdrawal of electron density) of the halogens present (bromine and fluorine) on 4-bromofluorobenzene cause deactivation of the benzene ring and direct reactivity to ''ortho and ''para'' positions on the ring.(Aromatic Reactivity ) This redirection of reactivity makes it useful as a precursor other compounds that serve a wide variety of needs.The bromine on 4-bromofluorobenzene allows it to become a Grignard reagent when reacted with magnesium metal.(Patent US4956507 - Grignard reagents from p-halofluorobenzene and magnesium coupling to form p ... - Google Patents ) Preparation of a Grignard reagent using it makes it useful as an intermediate in the synthesis of atypical antipsychotic agents (especially those with a 4-fluorophenyl moiety),(Patent US4605655 - Neuroleptic agents; no movement disorder side effects - Google Patents ) and in pesticides such as Flusilazole.(【引用サイトリンク】url=http://www.afineagro.com/cgi/search-en.cgi?f=product_en1+product_en_1_+company_en_1_+contact_en&id=576084&t=product_en_1_ )This compound is also used as a tuning solution, internal standard, and/or surrogate (a compound that is similar in chemical composition to the analyte(s) of interest and is spiked into environmental and batch quality control samples prior to sample preparation and analysis) in several EPA gas chromatography methods, such as those for drinking water, wastewater pollutants, and organic pollutant monitoring in groundwater, wastewater, and solid waste.
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4-Bromofluorobenzene is a halogenated aromatic organic compound with the formula C6H4BrF. It is a derivative of benzene, with a bromine atom bonded ''para'' to a fluorine atom. It has uses as a precursor to some pharmaceuticals, as an agrochemical intermediate, and in organic synthesis.〔(【引用サイトリンク】No. 460-00-4 ) Review of Toxicological Literature">url=http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/4-bfb_508.pdf )〕
==Uses==
The electronegativity (withdrawal of electron density) of the halogens present (bromine and fluorine) on 4-bromofluorobenzene cause deactivation of the benzene ring and direct reactivity to ''ortho and ''para'' positions on the ring.〔(Aromatic Reactivity )〕 This redirection of reactivity makes it useful as a precursor other compounds that serve a wide variety of needs.
The bromine on 4-bromofluorobenzene allows it to become a Grignard reagent when reacted with magnesium metal.〔(Patent US4956507 - Grignard reagents from p-halofluorobenzene and magnesium coupling to form p ... - Google Patents )〕 Preparation of a Grignard reagent using it makes it useful as an intermediate in the synthesis of atypical antipsychotic agents (especially those with a 4-fluorophenyl moiety),〔〔(Patent US4605655 - Neuroleptic agents; no movement disorder side effects - Google Patents )〕 and in pesticides such as Flusilazole.〔(【引用サイトリンク】url=http://www.afineagro.com/cgi/search-en.cgi?f=product_en1+product_en_1_+company_en_1_+contact_en&id=576084&t=product_en_1_ )〕
This compound is also used as a tuning solution, internal standard, and/or surrogate (a compound that is similar in chemical composition to the analyte(s) of interest and is spiked into environmental and batch quality control samples prior to sample preparation and analysis) in several EPA gas chromatography methods, such as those for drinking water, wastewater pollutants, and organic pollutant monitoring in groundwater, wastewater, and solid waste.〔
抄文引用元・出典: フリー百科事典『 url=http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/4-bfb_508.pdf )==Uses==The electronegativity (withdrawal of electron density) of the halogens present (bromine and fluorine) on 4-bromofluorobenzene cause deactivation of the benzene ring and direct reactivity to ''ortho and ''para'' positions on the ring.(Aromatic Reactivity ) This redirection of reactivity makes it useful as a precursor other compounds that serve a wide variety of needs.The bromine on 4-bromofluorobenzene allows it to become a Grignard reagent when reacted with magnesium metal.(Patent US4956507 - Grignard reagents from p-halofluorobenzene and magnesium coupling to form p ... - Google Patents ) Preparation of a Grignard reagent using it makes it useful as an intermediate in the synthesis of atypical antipsychotic agents (especially those with a 4-fluorophenyl moiety),(Patent US4605655 - Neuroleptic agents; no movement disorder side effects - Google Patents ) and in pesticides such as Flusilazole.(【引用サイトリンク】url=http://www.afineagro.com/cgi/search-en.cgi?f=product_en1+product_en_1_+company_en_1_+contact_en&id=576084&t=product_en_1_ )This compound is also used as a tuning solution, internal standard, and/or surrogate (a compound that is similar in chemical composition to the analyte(s) of interest and is spiked into environmental and batch quality control samples prior to sample preparation and analysis) in several EPA gas chromatography methods, such as those for drinking water, wastewater pollutants, and organic pollutant monitoring in groundwater, wastewater, and solid waste.">ウィキペディア（Wikipedia）』
■url=http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/4-bfb_508.pdf )==Uses==The electronegativity (withdrawal of electron density) of the halogens present (bromine and fluorine) on 4-bromofluorobenzene cause deactivation of the benzene ring and direct reactivity to ''ortho and ''para'' positions on the ring.(Aromatic Reactivity ) This redirection of reactivity makes it useful as a precursor other compounds that serve a wide variety of needs.The bromine on 4-bromofluorobenzene allows it to become a Grignard reagent when reacted with magnesium metal.(Patent US4956507 - Grignard reagents from p-halofluorobenzene and magnesium coupling to form p ... - Google Patents ) Preparation of a Grignard reagent using it makes it useful as an intermediate in the synthesis of atypical antipsychotic agents (especially those with a 4-fluorophenyl moiety),(Patent US4605655 - Neuroleptic agents; no movement disorder side effects - Google Patents ) and in pesticides such as Flusilazole.(【引用サイトリンク】url=http://www.afineagro.com/cgi/search-en.cgi?f=product_en1+product_en_1_+company_en_1_+contact_en&id=576084&t=product_en_1_ )This compound is also used as a tuning solution, internal standard, and/or surrogate (a compound that is similar in chemical composition to the analyte(s) of interest and is spiked into environmental and batch quality control samples prior to sample preparation and analysis) in several EPA gas chromatography methods, such as those for drinking water, wastewater pollutants, and organic pollutant monitoring in groundwater, wastewater, and solid waste.">ウィキペディアで「|Section2=|Section3=|Section7=|Section8=}}4-Bromofluorobenzene is a halogenated aromatic organic compound with the formula C6H4BrF. It is a derivative of benzene, with a bromine atom bonded ''para'' to a fluorine atom. It has uses as a precursor to some pharmaceuticals, as an agrochemical intermediate, and in organic synthesis.(【引用サイトリンク】No. 460-00-4 ) Review of Toxicological Literature">url=http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/4-bfb_508.pdf )==Uses==The electronegativity (withdrawal of electron density) of the halogens present (bromine and fluorine) on 4-bromofluorobenzene cause deactivation of the benzene ring and direct reactivity to ''ortho and ''para'' positions on the ring.(Aromatic Reactivity ) This redirection of reactivity makes it useful as a precursor other compounds that serve a wide variety of needs.The bromine on 4-bromofluorobenzene allows it to become a Grignard reagent when reacted with magnesium metal.(Patent US4956507 - Grignard reagents from p-halofluorobenzene and magnesium coupling to form p ... - Google Patents ) Preparation of a Grignard reagent using it makes it useful as an intermediate in the synthesis of atypical antipsychotic agents (especially those with a 4-fluorophenyl moiety),(Patent US4605655 - Neuroleptic agents; no movement disorder side effects - Google Patents ) and in pesticides such as Flusilazole.(【引用サイトリンク】url=http://www.afineagro.com/cgi/search-en.cgi?f=product_en1+product_en_1_+company_en_1_+contact_en&id=576084&t=product_en_1_ )This compound is also used as a tuning solution, internal standard, and/or surrogate (a compound that is similar in chemical composition to the analyte(s) of interest and is spiked into environmental and batch quality control samples prior to sample preparation and analysis) in several EPA gas chromatography methods, such as those for drinking water, wastewater pollutants, and organic pollutant monitoring in groundwater, wastewater, and solid waste.」の詳細全文を読む
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