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|Section2= |Section3= }} 4-Chloro-''o''-toluidine (4-COT, 4-chloro-2-methylaniline) is the organic compound with the formula CH3C6H3Cl(NH2). It is a colorless solid. The compound is produced as an intermediate to the pesticide chlordimeform and a precursor to some azo dyes. Production has declined after it was shown to be highly carcinogenic. == Production and use == It is produced by the chlorination reaction of N-aceyltoluidine followed by deprotection and separation from the 6-chloro isomer.〔Joseph S. Bowers, "Toluidines" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. 〕 Production of 4-chloro-''o''-toluidine began in Germany in 1924. In Switzerland, 4-COT and its salts were produced between 1956 and 1976. Production and distribution ceased in 1979 in the US and in 1986 in Germany. In nature, 4-COT is found in plants and animals as a metabolic product of chlordimeform.〔IARC Monograph Vol. 48, p-Chloro-o-Toluidine and its strong salts〕 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「4-Chloro-o-toluidine」の詳細全文を読む スポンサード リンク
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