翻訳と辞書 Words near each other ・ 5-25-77 ・ 5-3-2 ・ 5-4-3 rule ・ 5-4-3-2-Run ・ 5-5 duoprism ・ 5-7-9 ・ 5-alpha reductase ・ 5-alpha-reductase deficiency ・ 5-alpha-reductase inhibitor ・ 5-amino-6-(5-phosphoribosylamino)uracil reductase ・ 5-Aminoimidazole ribotide ・ 5-aminopentanamidase ・ 5-aminovalerate transaminase ・ 5-Androstenediol ・ 5-Androstenedione ・ 5-APB ・ 5-APDB ・ 5-APDI ・ 5-Benzyloxytryptamine ・ 5-beta-reductase ・ 5-Bromo-4-chloro-3-indolyl phosphate ・ 5-Bromo-DMT ・ 5-Bromouracil ・ 5-Bromouridine ・ 5-Carboxamidotryptamine ・ 5-carboxymethyl-2-hydroxymuconate Delta-isomerase ・ 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase ・ 5-cell ・ 5-cell honeycomb ・ 5-centimeter band Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 5-APB ： ウィキペディア英語版 5-APB 5-APB (5-(2-aminopropyl)benzofuran, 1-benzofuran-5-ylpropan-2-amine, benzofury) is a triple monoamine reuptake inhibitor with Ki values of 180, 265 and 811 nM for NET, DAT and SERT respectively as well as being a potent agonist for the 5-HT2A and 5-HT2B receptors (Ki of 14nM at 5-HT2B).〔Dawson P, Opacka-Juffry J, Moffatt JD, Daniju Y, Dutta N, Ramsey J, Davidson C. The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat. ''Progress in Neuropsychopharmacology and Biological Psychiatry''. 2014 Jan 3;48:57-63. doi: 10.1016/j.pnpbp.2013.08.013. PMID 24012617〕 This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA. The subjective effects and structure-activity relationship suggest that 5-APB is also a monoamine releasing agent. 5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass and doses should be adjusted accordingly. 5-APB is also an agonist of the 5-HT2C receptor as well as a triple monoamine reuptake inhibitor.〔 It has been sold as a designer drug since 2010.〔(EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA )〕 ==Detection== A forensic standard of 5-APB is available, and the compound has been posted on the Forendex website of potential drugs of abuse.〔Southern Association of Forensic Scientists, http://forendex.southernforensic.org/index.php/detail/index/1135〕 The US Department of Justice and DEA have also conducted studies concerning the detection of 5-APB.〔USDOJ/DEA, http://www.justice.gov/dea/pr/microgram-journals/2011/mj8-2_62-74.pdf〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「5-APB」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.