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・ 5-HT1D receptor agonist
・ 5-HT1E receptor
・ 5-HT1F receptor
・ 5-HT2 receptor
・ 5-HT2A receptor
・ 5-HT2B receptor
・ 5-HT2C receptor
・ 5-HT2c receptor agonist
・ 5-HT3 antagonist
・ 5-HT3 receptor
・ 5-HT4 receptor
・ 5-HT5A receptor
・ 5-HT5B receptor
・ 5-HT6 receptor
・ 5-HT7 receptor
5-HTTLPR
・ 5-Hydroxy-2(5H)-furanone
・ 5-Hydroxycytosine
・ 5-Hydroxyeicosanoid dehydrogenase
・ 5-Hydroxyferulic acid
・ 5-hydroxyfuranocoumarin 5-O-methyltransferase
・ 5-Hydroxyhydantoin
・ 5-Hydroxyicosatetraenoic acid
・ 5-Hydroxyindoleacetic acid
・ 5-Hydroxyisourate
・ 5-Hydroxymaltol
・ 5-Hydroxymethylcytosine
・ 5-hydroxypentanoate CoA-transferase
・ 5-Hydroxytryptophan
・ 5-Hydroxyuracil


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5-HTTLPR : ウィキペディア英語版
5-HTTLPR
5-HTTLPR (serotonin-transporter-linked polymorphic region) is a degenerate repeat polymorphic region in ''SLC6A4'', the gene that codes for the serotonin transporter.
Since the polymorphism was identified in the middle of the 1990s,
it has been extensively investigated, e.g., in connection with neuropsychiatric disorders.
A 2006 scientific article stated that "over 300 behavioral, psychiatric, pharmacogenetic and other medical genetics papers" had analyzed the polymorphism. While often discussed as an example of gene-environment interaction, this contention is contested.
== Alleles ==

The polymorphism occurs in the promoter region of the gene.
Researchers commonly report it with two variations in humans: A short ("s") and a long ("l"), but it can be subdivided further.
In connection with the region are two single nucleotide polymorphisms (SNP): rs25531 and rs25532.
One study published in 2000 found 14 allelic variants (14-A, 14-B, 14-C, 14-D, 15, 16-A, 16-B, 16-C, 16-D, 16-E, 16-F, 19, 20 and 22) in a group of around 200 Japanese and Caucasian people.〔
The difference between 16-A and 16-D is the rs25531 SNP.
It is also the difference between 14-A and 14-D.〔
Some studies have found that long allele results in higher serotonin transporter mRNA transcription in human cell lines.
The higher level may be due to the A-allele of rs25531, such that subjects with the long-rs25531(A) allelic combination (sometimes written LA) have higher levels while long-rs25531(G) carriers have levels more similar to short-allele carriers.
Newer studies examining the effects of genotype may compare the LA/LA genotype against all other genotypes. The allele frequency of this polymorphism seems to vary considerably across populations, with a higher frequency of the long allele in Europe and lower frequency in Asia. Despite speculation to the contrary, the population variation in the allele frequency is more likely due to neutral evolutionary processes than natural selection.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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