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5-MeO-NBpBrT : ウィキペディア英語版 | 5-MeO-NBpBrT
5-MeO-NBpBrT (5-Methoxy-N-(4-bromobenzyl)tryptamine) is a N-substituted member of the methoxytryptamine family of compounds. Like other such compounds it acts as an antagonist for the 5-HT2A receptor, with a claimed 100x selectivity over the closely related 5-HT2C receptor. While N-benzyl substitution of psychedelic phenethylamines often results in potent 5-HT2A agonists, N-benzyl tryptamines show much lower efficacy and are either very weak partial agonists or antagonists at 5-HT2A.〔(Maria Silva PhD. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009. )〕 Extending the benzyl group to a substituted phenethyl can however recover agonist activity in certain cases.〔(Niels Jensen. Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens. PhD dissertation, Georg-August-Universität zu Göttingen, 2004. )〕 ==See also==
* 25B-NBOMe * 25I-NBF * RH-34
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