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5-fluoro-α-methyltryptamine : ウィキペディア英語版
5-Fluoro-AMT

5-Fluoro-α-methyltryptamine (5-Fluoro-αMT), also known as PAL-544, is a putative stimulant, entactogen, and psychedelic tryptamine derivative related to α-methyltryptamine (αMT). It has been found to act as a well-balanced serotonin-norepinephrine-dopamine releasing agent, a 5-HT2A receptor agonist,〔Chairungsrilerd N, Furukawa K, Tadano T, Kisara K, Ohizumi Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. ''British Journal of Pharmacology. 1998 Mar;123(5):855-62.〕 and a potent and specific MAO-A inhibitor.〔Kinemuchi H, Arai Y. Selective inhibition of monoamine oxidase A and B by two substrate-analogues, 5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine. ''Research Communications in Chemical Pathology and Pharmacology''. 1986 Oct;54(1):125-8.〕〔Kim SK, Toyoshima Y, Arai Y, Kinemuchi H, Tadano T, Oyama K, Satoh N, Kisara K. Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons. ''Neuropharmacology''. 1991 Apr;30(4):329-35.〕 It produces a strong head-twitch response in mice, and this effect is known to correlate with psychedelic effects in humans,〔Corne SJ, Pickering RW. A possible correlation between drug induced hallucinations in man and a behavioral response in mice. ''Psychopharmacologia'' 1967, 11, 65-78.〕〔Yamamoto T, Ueki S. The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by halluinogenic drugs. ''Pharmacology, Biochemistry and Behaviour''. 1981, 14, 89-95.〕 which suggests that 5-fluoro-αMT could be an active psychedelic in humans, although it is not known to have been tested in humans and could be dangerous due to its strong inhibition of MAO-A.
==See also==

* 5-Chloro-αMT
* 5-Fluoro-DMT
* 7-Methyl-αET
* Flucindole
* 5-API (PAL-571)

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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