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Arachidonate 5-lipoxygenase, also known as 5-lipoxygenase, 5-LOX or 5-LO, is an enzyme that in humans is encoded by the ''ALOX5'' gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. == Substrates and products == EFA substrates and products of 5-LO include: * Arachidonic acid (AA) yields 5-hydroperoxyeicosatetraenoic acids (5-HpETE), 5-hydroxyeicosatetraenoic acids (5-HETE), 5-oxo-eicosatetraenoate (5-oxo-ETE), and the 4-series leukotrienes (LTB4, LTC4, LTD4, LTE4). * Eicosapentaenoic acid (EPA) yields the 5-series (LTB5, LTC5, LTD5, LTE5). * Gamma-linolenic acid (GLA ''via'' the DGLA intermediary) yields no leukotrienes, but inhibits the conversion of AA. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Arachidonate 5-lipoxygenase」の詳細全文を読む スポンサード リンク
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