| 翻訳と辞書 |
| 5-phosphoribosyl-1-pyrophosphate ： ウィキペディア英語版 |
Phosphoribosyl pyrophosphate
|Section2=
|Section3=
}}
Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.
It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.
It plays a role in transferring phospho-ribose groups in several reactions:
In ''de novo'' generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.
==Increased PRPP==
Increased levels of PRPP is characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria. It is one of the causes of gout.
Increased levels of PRPP are present in Lesch-Nyhan Syndrome. Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Phosphoribosyl pyrophosphate」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|