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5β-reductase : ウィキペディア英語版
5-beta-reductase

Delta4-3-oxosteroid 5beta-reductase (, ''3-oxo-Delta4-steroid 5beta-reductase'', ''5beta-reductase'', ''androstenedione 5beta-reductase'', ''cholestenone 5beta-reductase'', ''cortisone 5beta-reductase'', ''cortisone beta-reductase'', ''cortisone Delta4-5beta-reductase'', ''steroid 5beta-reductase'', ''testosterone 5beta-reductase'', ''Delta4-3-ketosteroid 5beta-reductase'', ''Delta4-5beta-reductase'', ''Delta4-hydrogenase'', ''4,5beta-dihydrocortisone:NADP+ Delta4-oxidoreductase'', ''3-oxo-5beta-steroid:NADP+ Delta4-oxidoreductase'') is an enzyme with system name ''5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase''. This enzyme catalyses the following chemical reaction
: (1) 5beta-cholestan-3-one + NADP+ \rightleftharpoons cholest-4-en-3-one + NADPH + H+
: (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ \rightleftharpoons cortisone + NADPH + H+
The human enzyme efficiently acts on progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites. It can also act on aldosterone, corticosterone and cortisol, to some extent.
== References ==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「5-beta-reductase」の詳細全文を読む



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