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| 6-(2-Aminopropyl)benzofuran ： ウィキペディア英語版 |
6-APB
6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB), also known as ''Benzofury,'' is an entactogenic compound of the phenethylamine and amphetamine classes. It is a recreational drug that is similar in structure to MDA, but differs in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned.
==Pharmacology==
6-APB is a triple monoamine reuptake inhibitor with Ki values of 117, 150 and 2698 nM for NET, DAT and SERT respectively as well as being a potent agonist for the 5-HT2B receptor (Ki 3.7 nM). The subjective effects and structure–activity relationship suggest that it is also a releasing agent.
The agonism for 5-HT2B makes it likely that 6-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists, such as fenfluramine and MDMA.〔〔 6-APB acts as an agonist of the 5-HT2C receptor, which may be responsible for its appetite suppression. While 6-APB is an agonist at all three 5-HT2 receptor subtypes, its affinity for 5-HT2B is significantly higher. It is both more potent and more selective over other serotonin receptors than the reference agonist, BW723C86, which is commonly used for research into 5-HT2B receptors.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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