翻訳と辞書 Words near each other ・ 6-APT ・ 6-Benzylaminopurine ・ 6-bolt main ・ 6-Br-APB ・ 6-carboxyhexanoate—CoA ligase ・ 6-carboxytetrahydropterin synthase ・ 6-CAT ・ 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide ・ 6-Chloro-MDMA ・ 6-cube ・ 6-cubic honeycomb ・ 6-demicube ・ 6-demicubic honeycomb ・ 6-Deoxy-5-ketofructose 1-phosphate synthase ・ 6-Deoxyerythronolide B synthase ・ 6-Diazo-5-oxo-L-norleucine ・ 6-digit UNESCO nomenclature ・ 6-EAPB ・ 6-endo-hydroxycineole dehydrogenase ・ 6-Fluoro-AMT ・ 6-Fluoro-DMT ・ 6-Fluoronorepinephrine ・ 6-Hydroxy-3-succinoylpyridine 3-monooxygenase ・ 6-Hydroxycyanidin ・ 6-Hydroxyflavone ・ 6-hydroxyhexanoate dehydrogenase ・ 6-Hydroxykynurenic acid ・ 6-Hydroxymelatonin ・ 6-Hydroxymellein ・ 6-hydroxymellein O-methyltransferase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 6-Diazo-5-oxo-L-norleucine ： ウィキペディア英語版 6-Diazo-5-oxo-L-norleucine 6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist, which was isolated originally from Streptomyces in a sample of Peruvian soil. It is a non-standard amino acid. The diazo compound was characterized in 1956 by Henry W Dion et al., who suggested a possible use in cancer therapy. This antitumoral efficacy was confirmed in different animal models. DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. The last clinical results were published in 2008, though not as DON monotherapy but in combination with a recombinant glutaminase. == Chemistry == DON is a water-soluble yellowish powder, which can be dissolved also in aqueous solutions of methanol, acetone or ethanol, but dissolution in absolute alcohols is difficult. Solutions of at least 50 µM DON in 0.9% NaCl are lightly yellowish. The crystalline form appears as yellowish greenish needles. The specific rotation is ()26D +21° (c = 5.4% in H2O). In phosphate buffer, pH 7 are the ultraviolet absorption maxima at 274 nm (E1%1 cm. 683) and 244 nm (E1%1 cm 376).〔〔'' DeWald HA and Moore AM: 6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. Preparation of L (D and L)-forms, '' in Am. Chem. Soc. Meeting, Dallas, 1956, p. 13M ''.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「6-Diazo-5-oxo-L-norleucine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.