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|Section2= }} 7-Hydroxymitragynine (mitragynine hydroxyindolenine) is a terpenoid indole alkaloid in the plant ''Mitragyna speciosa'', commonly known as Kratom. It has opioid agonistic activity. "The potency, calculated using pD (2) values, was 30-fold higher than that of mitragynine and 17-fold higher than that of morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of ''M. speciosa'' is mostly based on the activity of 7-hydroxymitragynine." 7-Hydroxymitragynine is orally active in animals as an analgesic, and produces normal opioid side effects including constipation, though significantly less than morphine, development of tolerance and withdrawal syndrome upon abstinence.〔 The O-acetyl ester (''Acetoxy''), 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist. == See also == * Mitragynine * Mitraphylline * β-prodine - molecule which overlays with 7-hydroxymitragynine's opioid QSAR 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「7-Hydroxymitragynine」の詳細全文を読む スポンサード リンク
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