翻訳と辞書 Words near each other ・ A-not-A question ・ A-not-B error ・ A-ok ・ A-One (band) ・ A-One (TV channel) ・ A-366,833 ・ A-372159 ・ A-40174 ・ A-412,997 ・ A-41988 ・ A-423,579 ・ A-68930 ・ A-7 & A-10 (Arizona) ・ A-77636 ・ A-796,260 ・ A-834,735 ・ A-836,339 ・ A-84,543 ・ A-86929 ・ A-90 Orlyonok ・ A-91 ・ A-971432 ・ A-A line ・ A-A-P ・ A-Acayipsin ・ A-B Emblem ・ A-B Helicopters A/W 95 ・ A-b-c-darian ・ A-Ba-Ni-Bi ・ A-bike Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク A-834,735 ： ウィキペディア英語版 A-834,735 A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids, with the 3-tetramethylcyclopropylmethanone group of A-834,735 and related compounds, imparts significant selectivity for CB2, with most compounds from this group found to be highly selective CB2 agonists with little affinity for CB1. However low nanomolar CB1 binding affinity is retained with certain heterocyclic 1-position substituents such as (N-methylpiperidin-2-yl)methyl (cf. AM-1220, AM-1248), or the (tetrahydropyran-4-yl)methyl substituent of A-834,735, resulting in compounds that still show significant affinity and efficacy at both receptors despite being CB2 selective overall.〔Dart M, ''et al.'' (2006). 1-Alkyl-3-keto-indoles: identification and in vitro characterization of a series of potent cannabinoid ligands. In ''2006 Symposium on the Cannabinoids''. International Cannabinoid Research Society: Burlington, VT.〕〔 〕〔 〕 ==Legal Status== As of October 2015 A-834,735 is a controlled substance in China. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「A-834,735」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.