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AB-005
AB-005 or (2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (''K''i = 5.5 nM) and CB2 receptors (''K''i = 0.48 nM).〔 〕 AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans. ==Legal status== Psychoactive products in New Zealand containing this drug have been given interim approval under recent psychoactive substances legislation.〔Ministry of Health – Manatū Hauora ("Interim Product Approvals" ), ''Ministry of Health NZ'', New Zealand, 2 January 2013. Retrieved on 2 January 2013.〕
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