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ACCN1 : ウィキペディア英語版
ACCN1

Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ''ACCN1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=40 )〕 It is also known as an acid-sensing ion channel, ASIC2.〔(【引用サイトリンク】title=ASIC2 acid sensing (proton gated) ion channel 2 (Homo sapiens (human) ) )〕
== Function ==

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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