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ACOT11
Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ''ACOT11'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26027 )〕 This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.〔
==Structure==
The ACOT11 gene is located on the 1st chromosome, with its specific localization being 1p32.3. It contains 18 exons.〔
The protein encoded by this gene contains 258 amino acids, and forms a homodimer with another chain. Its theoretical weight is 26.67 kDa.〔(【引用サイトリンク】url=http://www.ebi.ac.uk/pdbe/entry/pdb/3FO5 )〕 The protein contains a StAR-related transfer domain, which is a domain responsible for binding to lipids. There are 4 known ligands that bind to this homodimer: polyethylene glycol, chlorine, glycerol, and a form of TCEP.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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