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ADAMTS ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) is a family of peptidases. 19 members of this family have been identified in humans. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Family members are: *ADAMTS1 *ADAMTS2 *ADAMTS3 *ADAMTS4 *ADAMTS5 (=ADAMTS11) *ADAMTS6 * ADAMTS7 *ADAMTS8 (or METH-2), an antiangiogenic〔(METH-2 silencing and promoter hypermethylation in NSCLC )〕 *ADAMTS9 *ADAMTS10 *ADAMTS12 *ADAMTS13 *ADAMTS14 *ADAMTS15 *ADAMTS16 *ADAMTS17 *ADAMTS18 *ADAMTS19 *ADAMTS20 ==See also==
* A disintegrin and metalloproteinase (ADAM) family
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「ADAMTS」の詳細全文を読む
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