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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク ADH-1 ： ウィキペディア英語版 ADH-1 ADH-1 (brand name ''Exherin'') is a small, cyclic pentapeptide vascular-targeting drug. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.〔(【引用サイトリンク】 ADH-1 )〕 N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell–cell adhesion and signaling mechanisms;〔 may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.〔 In a pilot study (phase I trial) at Duke Comprehensive Cancer Center, ADH-1 intravenous pretreatment before chemotherapy in metastatic melanoma completely destroyed tumors in half the patients, normally a very deadly cancer. It is being investigated for advanced extremity melanoma in phase II trials.〔(Physorg:Drug combination may be effective against deadly melanoma, pilot study shows )〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ADH-1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.