|
Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ''ADH1B'' gene. The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=125 )〕 The human gene is located on chromosome 4 in 4q22. Previously ''ADH1B'' was called ''ADH2''. There are more genes in the family of alcohol and aldehyde dehydrogenase genes. These genes are now referred to as ''ADH1A'', ''ADH1C'', and ''ADH4'', ''ADH5'', ''ADH6'' and ''ADH7''. == Variants == A single nucleotide polymorphism (SNP) in ''ADH1B'' is rs1229984, that changes arginine to histidine at residue 47. The 'typical' variant of this has been referred to as ADH2(1) or ADH2 *1 while the 'atypical' has been referred to as, e.g., ADH2(2), ADH2 *2, ADH1B *47his, or ADH1B arg47-to-his. This SNP may be related to alcohol consumption with the atypical genotype having reduced risk of alcoholism. Another SNP is Arg369Cys. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ADH1B」の詳細全文を読む スポンサード リンク
|