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ALOX15B
Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ''ALOX15B'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247 )〕 ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.
== Function ==
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.〔 15-LOX-2 converts arachidonic acid almost exclusively to the ''S'' stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the ''S'' stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the ''S'' stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the ''S'' stereoisomer of 13-Hydroxyoctadecadienoic acid.〔 The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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