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AM-411 is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk. AM-411 is a potent and fairly selective CB1 full agonist with a Ki of 6.80nM, but is still also a moderately potent CB2 agonist with a Ki of 52.0nM.〔Lu D, ''et al.'' Adamantyl cannabinoids: a novel class of cannabinergic ligands. ''Journal of Medicinal Chemistry''. 2005 Jul 14;48(14):4576-85. PMID 15999995〕 It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.〔Järbe TU, DiPatrizio NV, Lu D, Makriyannis A. (−)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats. ''Behavioural Pharmacology''. 2004 Nov;15(7):517-21. PMID 15472574〕〔McLaughlin PJ, ''et al.'' Behavioral effects of the novel cannabinoid full agonist AM 411. ''Pharmacology, Biochemistry and Behaviour''. 2005 May;81(1):78-88. PMID 15894067〕 ==See also== * AM-087 * AM-1248 * KM-233 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AM-411」の詳細全文を読む スポンサード リンク
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