翻訳と辞書 Words near each other ・ AM-906 ・ AM-919 ・ AM-938 ・ AM-Franc ・ Am-heh ・ AM-Lira ・ AM-Mark ・ Am-Pol Eagle Citizen of the Year Award ・ AM/FM/GIS ・ AM1 ・ AM1* ・ AM1200 ・ AM1200 (film) ・ AM1x ・ AM2 ・ AM251 ・ Am286 ・ Am386 ・ AM3D A/S ・ AM4 ・ AM404 ・ Am486 ・ AM5-M2 ・ Am5x86 ・ Am730 ・ AM936 ・ Ama ・ Ama (ayurveda) ・ Ama (diving) ・ Ama (sailing) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク AM251 ： ウィキペディア英語版 AM251 AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB1 receptor (with a Ki value of 7.5nM) than SR141716A, which has a Ki value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB1 receptor when compared to SR141716A.〔Lan, R., Liu, Q., Fan, P., et al. Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 42 769-776 (1999). 〕 Like SR141716A, it is additionally a μ-opioid receptor antagonist.〔(AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. ) Neuropharmacology. 2012 Oct;63(5):905-15. doi: 10.1016/j.neuropharm.2012.06.046. Epub 2012 Jul 4. PMID 22771770 PMCID: PMC3408547〕 ==See also== * Discovery and development of Cannabinoid Receptor 1 Antagonists 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AM251」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.