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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク AMPT ： ウィキペディア英語版 AMPT Alpha-methyl-p-tyrosine (AMPT) is a tyrosine hydroxylase enzyme inhibitor. Alpha-methyl-p-tyrosine (AMPT) is a non-endogenous drug involved in the catecholamine biosynthetic pathway.〔(Eric J., Steven E. Hyman, and Robert C. Malenka. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. New York: McGraw-Hill, Medical Pub. Div., 2001. ),additional text.〕 AMPT inhibits tyrosine hydroxylase whose enzymatic activity is regulated through the phosphorylation of different serine residue regulatory domain sites.〔 Catecholamine biosynthesis starts with dietary tyrosine, which is hydroxylated by the enzyme tyrosine hydroxylase. It is hypothesized that AMPT competes with tyrosine at the tyrosine-binding site, causing inhibition of tyrosine hydroxylase.〔(R., and M. F. Salvatore. "Low Dose Alpha-Methyl-Para-Tyrosine (AMPT) in the Treatment of Dystonia and Dyskinesia." Journal of Neuropsychiatry 19.1 (2007): 65-69. ), additional text.〕 It has been used in the treatment of pheochromocytoma.〔 It has been demonstrated to inhibit the production of melanin.〔(Use of α-methyl-p-tyrosine to inhibit melanin production in iris melanocytes )〕 ==Pharmacology== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AMPT」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.