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ANG1005
ANG1005 is a experimental chemotherapy drug that is under development by a biotechnology company located in Montreal, Canada known as Angiochem Inc. This drug is inserted intravenously and is currently in early clinical stages of development and dose escalation.〔(【引用サイトリンク】title=Angiochems ANG1005 Demonstrates Preliminary Clinical Safety and Tolerability in Brain Cancers )〕 However, ANG1005 consists of a 19 amino acid long peptide vector known as Angiopep that is conjugated to a taxane derivative involved in mitotic inhibition known as paclitaxel. Various Angiopep vectors have been composed but solely differ by their anti-cancer moieties. This has then been shown to be a prospective cancer therapy drug that can not only be conjugated to paclitaxel but also peptides, monoclonal antibodies, siRNA and many other biological aspects. ANG1005 will then possess the potential to treat a variety of CNS diseases including glioma.〔(【引用サイトリンク】title=ANG1005 - A Promising New Targeted Taxane Derivative )〕 Research has shown reduction in tumour growth in mice and rats with glioblastoma tumors.
==Potential use==
This drug was specifically designed to treat brain tumors. Because of the blood brain barrier (BBB), many cancer therapy drugs are prevented from passing through the brain capillaries into the parenchyma.〔(【引用サイトリンク】title=Uptake of ANG1005, a Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer )〕 Paclitaxel is generally prevented from reaching its target in the cell due to the presence of the efflux pump P-glycoprotein (P-gp) at the barrier. This is known as a multidrug resistant-associated protein (MRP1) that causes resistance amongst many organic drugs that are not conjugated to acidic ligands.〔(【引用サイトリンク】title=Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain )〕 This receptor is an ATP-driven transporter that will pump drugs, drug metabolites, and endogenous metabolites out of the cell.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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