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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク ANKRD2 ： ウィキペディア英語版 ANKRD2 Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ''ANKRD2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26287 )〕 ARPP is a member of the muscle ankyrin repeat proteins (MARP), which also includes CARP and DARP, and is highly expressed in cardiac and skeletal muscle and in other tissues. Expression of AARP has been shown to be altered in patients with dilated cardiomyopathy and amyotrophic lateral sclerosis. ==Structure== Two isoforms of ARPP have been documented; a 39.8 kDa protein isoform composed of 360 amino acids〔(【引用サイトリンク】url=http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=Q9GZV1 )〕 and a 36.2 kDa protein isoform composed of 327 amino acids.〔(【引用サイトリンク】url=http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=Q9GZV1-2 )〕 ''ANKRD2'' has nine exons, four of which encode ankyrin repeats in the middle region of the protein, a PEST-like and Lysine-rich sequence in the N-terminal region, and a Proline-rich sequence containing consensus sequences for phosphorylation in the C-terminal region. It has been proposed that AARP can homo- or hetero-dimerize with other MARPs in an antiparallel fashion. ARPP is highly expressed in nuclei and I-bands in slow skeletal fibers〔 and cardiac muscle, specifically in ventricular regions〔 at intercalated discs; and expression in brain, pancreas and esophageal epithelium has also been documented.〔 Though AARP and CARP proteins show significant homology, their expression profiles in muscle cells are markedly different; CARP is expressed throughout atria and ventricles, in development and in adult myocytes, however AARP is almost exclusively ventricular and only in adult myocytes. AARP was also found to be expressed in rhabdomyosarcomas, exhibiting a pattern distinct from actin and desmin. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ANKRD2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.