翻訳と辞書 Words near each other ・ Apachyidae ・ Apachyus ・ Apacilagua ・ Apaconjunctdonta ・ Apacunca Genetic Reserve ・ Apadana ・ Apadana (disambiguation) ・ Apadana Complex ・ Apadhup ・ Apadmi ・ Apadravya ・ Apadrinar en Perú ・ Apadāna ・ Apaecasia ・ Apaegocera ・ APAF1 ・ Apaga ・ Apaga River ・ Apaga, Armenia ・ Apagado ・ Apage ・ Apagesoma ・ Apagobelus ・ Apagomera ・ Apagomerella ・ Apagomerina ・ Apagorevmeno ・ Apagorevmeno (song) ・ Apagy ・ Apagón Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク APAF1 ： ウィキペディア英語版 APAF1 Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of ''C. elegans'' CED-4 gene.〔 == Function == This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves Procaspase 9 protein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「APAF1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.