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APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionarily conserved proteins. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalytic domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to form the editosome. A recent review discussed the structural and biophysical aspects of APOBEC3 family enzymes. Much of the APOBEC protein features are described in the widely studied APOBEC3G's page. == Family members== Human genes encoding members of the APOBEC protein family include: * APOBEC1 * APOBEC2 * APOBEC3A * APOBEC3B * APOBEC3C * APOBEC3D ("APOBEC3E" now refers to this) * APOBEC3F * APOBEC3G * APOBEC3H * APOBEC4 * Activation-induced (cytidine) deaminase 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「APOBEC」の詳細全文を読む スポンサード リンク
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