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AR-A000002
AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT1B,〔Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C. Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. ''Journal of Pharmacology and Experimental Therapeutics''. 2003 Mar;304(3):1072-84. PMID 12604684〕 with approximately 10x selectivity for 5-HT1B over the closely related 5-HT1D receptor.〔Ahlgren C, Eriksson A, Tellefors P, Ross SB, Stenfors C, Malmberg A. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. ''European Journal of Pharmacology''. 2004 Sep 19;499(1-2):67-75. PMID 15363952〕 It has been shown to produce sustained increases in levels of serotonin in the brain, and has anxiolytic effects in animal studies.〔Stenfors C, Ahlgren C, Yu H, Wedén M, Larsson LG, Ross SB. Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs. ''Psychopharmacology (Berlin)''. 2004 Mar;172(3):333-40. PMID 14652708〕〔Stenfors C, Hallerbäck T, Larsson LG, Wallsten C, Ross SB. Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. ''Naunyn Schmiedebergs Archives of Pharmacology''. 2004 Mar;369(3):330-7. PMID 14758468〕
== References ==
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