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Acetylserotonin O-methyltransferase
N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.〔 (also comments in Thomson's website )〕
In humans the ASMT enzyme is encoded by the ''ASMT'' gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.
==Structure and Gene Location==
''N-Acetylserotonin O-methyltransferase'' is an enzyme that is coded for by genes located on the pseudoautosomal region of the X and Y chromosome, and is most abundantly found in the pineal gland and retina of humans.
Although the exact structure of ''N- Acetylserotonin O-methyltransferase'' has yet to be determined by X-Ray diffraction, the crystal structure of the Maf domain of human ''N-Acetylserotonin O-methyltransferase''-like protein has been found.〔; Min J, Wu H, Dombrovski L, Loppanu P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarve A, Plotnikov AM, Crystal Structure of Maf Domain of Human N- Acetylseratonin O-methyltransferase, Structural Genomics Consotrium (SGC) (2007)〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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