翻訳と辞書 Words near each other ・ AT&T Pebble Beach National Pro-Am ・ AT&T Performing Arts Center ・ AT&T Plaza ・ AT&T Plaza (disambiguation) ・ AT&T Pogo ・ AT&T Sceptre ・ AT&T Stadium ・ AT&T Switching Center ・ AT&T Team USA Soundtrack ・ AT&T Team USA Soundtrack (2010) ・ AT&T Technologies ・ AT&T Tower (Minneapolis) ・ AT&T U-verse ・ AT&T Unix PC ・ AT&T Wireless Services ・ AT-076 ・ AT-10 resin ・ AT-11 ・ AT-12 ・ AT-16 ・ AT-3 ・ AT-4 ・ AT-43 ・ AT-5 ・ AT-6 ・ AT-7 ・ AT-8 ・ AT-8 (Cuban mine) ・ AT-84 ・ AT-88 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク AT-076 ： ウィキペディア英語版 AT-076 AT-076 is a so-called opioid "pan" antagonist and is the first reasonably balanced antagonist known of all four opioid receptor types. It acts as a silent antagonist of all four of the opioid receptors, behaving as a competitive antagonist of the μ-opioid receptor (Ki = 1.67 nM) and δ-opioid receptor (Ki = 19.6 nM) and as a noncompetitive antagonist of the κ-opioid receptor (Ki = 1.14 nM) and nociceptin receptor (Ki = 1.75 nM).〔 AT-076 was derived from the selective κ-opioid receptor antagonist JDTic via removal of the 3,4-dimethyl group of the ''trans''-(3''R'',4''R'')-dimethyl-4-(3-hydroxyphenyl)piperidine antagonist scaffold, which increased affinity for the nociceptin receptor by 10-fold and for the μ- and δ-opioid receptors by 3-6-fold.〔 ==See also== * Cebranopadol * Buprenorphine * BU09059 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AT-076」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.