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Acetoacetyl-CoA : ウィキペディア英語版 | Acetoacetyl-CoA
|Section2= |Section3= }} Acetoacetyl CoA is the precursor of HMG-CoA in the Mevalonate pathway, which is essential for cholesterol synthesis. It also takes a similar role in the ketone bodies synthesis pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant. It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. During the metabolism of leucine, this last reaction is reversed. ==See also==
* Mevalonate pathway * Acetoacetic acid * Beta-hydroxybutyryl-CoA dehydrogenase
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